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KMID : 0880220070450040364
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Journal of Microbiology
2007 Volume.45 No. 4 p.364 ~ p.366
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Immunological Roles of Pasteurella multocida Toxin (PMT) Using a PMT Mutant Strain
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Kim Tae-Jung
Toan Nguyen Tat
Jang Eun-Jin
Jung Bock-Gie
Lee Jae-Il
Lee Bong-Joo
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Abstract
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The immunological role of the Pasteurella multocida toxin (PMT) in mice was examined using a PMT mutant strain. After a nasal inoculation, the mutant strain failed to induce interstitial pneumonia. Moreover, PMT had no significant effect on the populations of CD4+, CD8+, CD3+, and CD19+ immunocytes in blood or on the populations of CD4+ and CD8+ splenocytes (P<0.01). However, there was a significant increase in the total number of cells in the BAL samples obtained from the wild-type P. multocida-inoculated mice. On the other hand, the level of IL-1 expression decreased when the macrophages from the bronchio-alveolar lavage were stimulated with PMT. Overall, PMT appears to play some role (stimulating and/or inhibiting) in the immunological responses but further studies will be required to confirm this
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KEYWORD
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knock-out, Pasteurella multocida toxin (PMT), sub-population, toxA
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